منابع مشابه
Cardiomyocyte cell cycle regulation.
Although rapid progress is being made in many areas of molecular cardiology, issues pertaining to the origins of heart-forming cells, the mechanisms responsible for cardiogenic induction, and the pathways that regulate cardiomyocyte proliferation during embryonic and adult life remain unanswered. In the present study, we review approaches and studies that have shed some light on cardiomyocyte c...
متن کاملCardiomyocyte cell cycle
The adult mammalian heart has a limited capacity for replacing lost tissue following injury. Mammalian cardiomyocytes exit the cell cycle shortly after birth, where they undergo a final round of DNA synthesis, binucleate, and terminally differentiate. In addition, low levels of cardiomyocyte turnover in the aging heart or following injury seem to be mediated mostly by cardiomyocyte division. Al...
متن کاملCardiomyocyte Cell-Cycle Activity during Preadolescence
Earlier studies (Soonpaa et al., 1996) revealed a rapid drop-off of ventricular cardiomyocyte cell-cycle activity at birth in mice, followed by a burst of DNA synthesis during the first week of postnatal life which contributed to the formation of multi-nucleated cardiomyocytes by postnatal day 10 (PN10). It has recently been suggested that a second burst of cardiomyocyte cell-cycle activity occ...
متن کاملRegulation of cardiomyocyte mechanotransduction by the cardiac cycle.
BACKGROUND Overloading the left ventricle in systole (pressure overload) is associated with a distinct morphological response compared with overload in diastole (volume overload). METHODS AND RESULTS We designed a novel computer-controlled experimental system that interfaces biaxially uniform strain with electrical pacing, so that cellular deformation can be imposed during a specified phase o...
متن کاملUnderstanding the molecular basis for cardiomyocyte cell cycle regulation: new insights in cardiac regeneration after injury?
Author for correspondence: Center for Regenerative Medicine in Barcelona, Dr. Aiguader, 88, 08003, Barcelona, Spain and Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 93027, USA Tel.: +1 858 453 4100 Fax: +1 858 453 2573 [email protected] [email protected] 20% of the ventricle. To directly identify the source of newly formed card...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2002
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000020201.44772.67